Alexander Pertsemlidis, Ph.D.

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RESEARCH

We integrate in vitro, in vivo and in silico approaches to study noncoding RNA regulation of cell viability and drug response in cancer, aimed at developing sensitive, non-invasive methods for the early detection of cancer and novel therapeutic agents targeting specific cancer subtypes. Our long-term goals are the identification of noncoding RNAs for which serum expression is a biomarker of the presence or progression of tumors or of the likely response of a tumor to drug treatment, and of noncoding RNA mimics or inhibitors that can be delivered as therapeutic agents for the treatment of tumors, either independently or as adjuvants to conventional therapeutics.

Selected Publications

Borkowksi R, Du L, Zhao Z, McMillan E, Kosti A, Yang CR, Suraokar M, Wistuba I, Minna JD, White MA, Pertsemlidis AGenetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling. Cancer Research 2015;75(4):1-10. 

Du L, Borkowski R, Zhao Z, Ma X, Yu X, Xie XJ, Pertsemlidis A. A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biol. 2013 Nov;10(11):1700-13.

Du L, Zhao Z, Ma X, Hsiao TH, Chen Y, Young E, Suraokar M, Wistuba I, Minna JD, Pertsemlidis A. miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene.  2014;33(34):4307-4315.

Du L, Subauste MC, DeSevo C, Zhao Z, Baker M, Borkowski R, Schageman JJ, Greer R, Yang CR, Suraokar M, Wistuba II, Gazdar AF, Minna JD, Pertsemlidis A. miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One. 2012;7(6):e39167. 

Du L, Schageman JJ, Irnov, Girard L, Hammond SM, Minna JD, Gazdar AF, Pertsemlidis A. MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J Exp Clin Cancer Res. 2010 Jun 17;29:75.

Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A, Kurie JM. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 2009 Sep 15;23(18):2140-51.

Zhao Z, Ma X, Hsiao TH, Lin G, Kosti A, Chen Y, Tomlinson G, Pertsemlidis A, Du L. A high-content morphological screen identifies novel microRNAs that control neuroblastoma cell differentiation. Oncotarget 2014;5(9):2499-512. 

Associate Professor
Pediatrics/Hematology-Oncology
Greehey CCRI

Education

Ph.D., Biophysics, University of California, 1995

M.S., Cellular and Molecular Biology, University of Michigan, 1988

B.S., Medieval History, Princeton University, 1987

Contact

Email: PERTSEMLIDIS@UTHSCSA.EDU

Phone: 210-562-9062


Research Profile
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