A specialist in both breast cancer and malignancies of the brain and spinal cord, Dr. Andrew Brenner not only focuses on clinical management, but also on the development of novel therapies to treat breast cancers and central nervous system tumors. A graduate of Texas A&M University, he earned his bachelorâ€™s degree in biochemistry and went on to earn his doctorate in biological science and tumor biology at The University of Texas M.D. Anderson Cancer Center - Science Park.
His doctoral thesis focused on the role of the cyclin dependent kinase inhibitor p16INK4a in mammary tumorigenesis and immortilization. Dr. Brennerâ€™s current interests have transitioned from cell cycle to the effect of hypoxia on chemokines and escape from antiangiogenics and the role of obesity in promoting breast tumorigenesis. Dr. Brenner received his medical degree from the Texas Tech University Health Sciences Center and completed a residency in internal medicine at Scott and White Hospital in Lubbock. He completed his fellowship in hematology and medical oncology at the UT Health Science Center.
Son C, Samples D, Brenner AJ, Floyd JR. Osteolytic calvarial lesions as initial presentation of latent neurosyphilis. J Clin Neurosci 2015 May;22(5):909-910.
Bowers LW, Brenner AJ, Hursting SD, Tekmal RR, deGraffenried LA. Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production. Breast Cancer Res Treat 2015 Jan;149(1):49-57.
Malik L, Mejia A, Parsons HM, Ehler B, Mahalingam D, Sarantopoulos J, Brenner AJ, Weitman SD. Predicting success in regulatory approval from Phase I results. Cancer Chemother Pharmacol 2014 Nov;74(5):1099-1103.
Bowers, LW, Maximo IX, Brenner AJ, Beeram M, Husrtin SD, Price RS, Tekmal RR, Jolly CA, deGraffenried LA. NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin-Aromatase Interactions. Cancer Research 2014 Aug;74(16).
Malik L, Parsons H, Mahalingam D, Ehler B, Goros M, Mejia A, Brenner A, Sarantopoulos J. Clinical Outcomes and Survival of Advanced Renal Cancer Patients in Phase I Clinical Trial Clin Genitourin Cancer. 2014 Feb;(14):19-26.
Bowers LW, Cavazos DA, Brenner AJ, Hursting SD, Maximo IXF, deGraffenried LA. Obesity enhances nongenomic estrogen receptor crosstalk with the PI3K/Akt and MAPK pathways to promote in vitro measures of breast cancer progression. Breast Cancer Research 2013 Aug;15(5).
Brenner AJ, Cohen YC, Breitbart E, Bangio L, Sarantopoulos J, Giles FJ, Borden EC, Harats D, Triozzi PL. Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors. Clin Cancer Res 2013 Jul;19(14):3996-4007.