Dr. Benjamin J. Daniel is the Director of the Institutional Flow Cytometry Facility and a Research Assistant Professor in the department of Molecular Medicine at the University of Texas Health Sciences Center at San Antonio. He has more than 16 years of experience in flow cytometry and immunological research in the context of host/pathogen immune responses. More recently, his research entailed studying the dysfunction of the aged immune system in response to cancer. His current research includes modulation of T cell exhaustion to improve anti-cancer therapies in aging.
His previous research included the study of tumor immune dysfunction, or how the tumor subverts oneâ€™s normal immunity into benefiting that of the tumor. He currently serves on the Flow Cytometry Core Managers Task force for the International Society for Analytical Cytometry (ISAC). He is also on the organizational committee for FlowTex; a Texas-based annual flow cytometry conference.
Barsky, L. W., M. Black, M. Cochran, B. J. Daniel, D. Davies, M. DeLay, R. Gardner, M. Gregory, D. Kunkel, J. Lannigan, J. Marvin, R. Salomon, C. Torres, and R. Walker. 2016. International Society for Advancement of Cytometry (ISAC) flow cytometry shared resource laboratory (SRL) best practices. Cytometry Part A 1â€“14.
Gao, H., Dong, Q., Chen, Y., Zhang, F., Wu, A., Shi, Y., Bandyopadhyay, A., Daniel, BJ., Huang, C., Sun ., 2016 Murine mammary stem/progenitor cell isolation: Different method matters? Springerplus 5: 140.
De Angulo, A., R. Faris, B. Daniel, C. Jolly, and L. DeGraffenried. 2015. Age-related increase in IL-17 activates pro-inflammatory signaling in prostate cells. Prostate 75: 449â€“462.
Nair, S., S. C. Nkhoma, D. Serre, P. A. Zimmerman, K. Gorena, B. J. Daniel, F. Nosten, T. J. C. Anderson, and I. H. Cheeseman. 2014. Single-cell genomics for dissection of complex malaria infections. Genome research 24: 1028â€“1038.
Mahalingam, D., L. Malik, M. Beeram, J. Rodon, K. Sankhala, A. Mita, D. Benjamin, N. Ketchum, J. Michalek, A. Tolcher, J. Wright, and J. Sarantopoulos. 2014. Phase II study evaluating the efficacy, safety, and pharmacodynamic correlative study of dual antiangiogenic inhibition using bevacizumab in combin... - PubMed - NCBI. Cancer Chemother Pharmacol 74: 77â€“84.
De Angulo, A., R. Faris, D. Cavazos, C. Jolly, B. Daniel, and L. Degraffenried.. Age-related alterations in T-lymphocytes modulate key pathways in prostate tumorigenesis. 2013 Prostate. Vol. 73 (8) pp.855-864
Brumlik, M. J., S. Pandeswara, S. M. Ludwig, D. P. Jeansonne, M. R. Lacey, K. Murthy, B. J. Daniel, R. F. Wang, S. R. Thibodeaux, K. M. Church, V. Hurez, M. J. Kious, B. Zhang, A. Alagbala, X. Xia, and T. J. Curiel. 2013. TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-gamma-mediated nitric oxide production. Exp Parasitol.
Daniel, B. J.*, Hurez, V.*, Sun, L., Liu, A.J., Ludwig, S.M., Kious, M.J., Thibodeaux, S.R., Pandeswara, S., Murthy, K., Livi, C.B., Wall, S., Brumlik, M.J., Shin, T., Zhang, B., Curiel, T.J., Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice. Cancer research 2012 72:2089-2099.
Jin, D., J. Fan, L. Wang, L. F. Thompson, A. Liu, B. J. Daniel, T. Shin, T. J. Curiel, and B. Zhang. CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression Cancer Research 2010 70:2245-2255.
Daniel, B. J., S. Pandeswara, M. J. Brumlik, A. Liu, S. R. Thibodeaux, S. M. Ludwig, X. Sun, and T. J. Curiel. A simple method to detect Toxoplasma gondii-specific cytotoxic T cells in vivo. Journal of immunological methods 2010; 355:86-90.
Ruter, J., Barnett, B. G., Kryczek, I., Brumlik, M. J., Daniel, B. J., Coukos, G., Zou, W., and Curiel, T. J. Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines. Front Biosci 2009.14:1761-1770.
Brumlik MJ, Daniel BJ, Waehler R, Curiel DT, Giles FJ, Curiel TJ. Trends in immunoconjugate and ligand-receptor based targeting development for cancer therapy. Expert Opin Drug Deliv 2008 Jan;5(1):87-103.
Barnett BG, RÃ¼ter J, Kryczek I, Brumlik MJ, Cheng PJ, Daniel BJ, Coukos G, Zou W, Curiel TJ, Brumlik M. Regulatory T cells: a new frontier in cancer immunotherapy. Adv Exp Med Biol 2008 Jan;622:255-260.
Wei S, Daniel BJ, Brumlik MJ, Burow ME, Zou W, Khan IA, Wadsworth S, Siekierka J, Curiel TJ. Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection. Antimicrob Agents Chemother 2007 Dec;51(12):4324-4328.
Ruter J, Barnett BG, Kryczek I, Brumlik M, Daniel BJ, Coukos G, Zou W, Curiel TJ. Manipulating T Regulatory Cells in Cancer Immunotherapy Exp Rev Derm 2006 Aug;1(4):589-597(9).
Wei S, Kryczek I, Daniel BJ, Cheng P, Mottram P, Curiel TJ, Lange A, Zou W. Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma Cancer Research 2005 Jun;65(12):5020-5026.
Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S, Kryczek I, Daniel B, Gordon A, Myers L, Lackner A, Disis ML, Knutson KL, Chen L, Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004 Sep;10(9):942-949.
Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, David O, Burow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Hemminki A, Alvarez RD, Emilie D, Curiel DT, Chen L, Zou W. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003 May;9(5):562-567.
Wei S, Marches F, Daniel BJ, Sonda S, Heidenreich K, Curiel TJ. Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication. Int J Parasitol 2002 Jul;32(8):969-977.