Research in the Dr. Charles France's lab focuses on interactions between
behavior and pharmacology and how those interactions impact the abuse
liability of drugs.
The lab's major goal is to understand how the subjective
and other abuse-related effects of drugs change as a consequence of
particular behavioral and pharmacologic histories. Behavioral procedures
developed in this laboratory permit systemic investigation of drug
dependence and withdrawal and ongoing studies examine how these
phenomena can be modified by behavioral and pharmacologic interventions.
Tanno T, Maguire DR, Henson C, France CP. Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentation. Psychopharmacology (Berl). 2014 Jan;231(1):85-95.
Gerak LR, France CP. Discriminative stimulus effects of pregnanolone in rhesus monkeys. Psychopharmacology (Berl). 2014 Jan;231(1):181-90.
Serafine KM, France CP. Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. Behav Pharmacol. 2014 Feb;25(1):44-52.
Baladi MG, Newman AH, France CP. Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats. Psychopharmacology (Berl). 2014 Feb;231(3):581-91.
Zanettini C, France CP, Gerak LR. Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: Determination of the functional half life of flumazenil. Eur J Pharmacol. 2014 Jan 15;723:405-9.