mesolimbic dopamine system regulates cognitive, motivational and behavioral
processes critical to normal functioning. Dysfunction in this system has been
linked to a number of psychiatric disorders including schizophrenia. Our
research is focused on trying to better understand the regulation of the
dopamine system in both normal and disease states. Using a combination of
techniques including, in vivo electrophysiology, molecular biology and behavior
we are attempting to develop novel treatments for schizophrenia. This includes
pharmacological, neurosurgical and cell based methods. We strongly believe that
a better understanding of the pathophysiology associated with neuropsychiatric
disease is essential for the development of novel therapeutic approaches.
Chen L, Perez SM, Lodge DJ. An augmented
dopamine system function is present prior to puberty in the MAM rodent model of
schizophrenia. Developmental Neurobiology. 2014 - In Press.
Perez SM, Lodge DJ. Hippocampal interneuron
transplants reverse aberrant dopamine system function and behavior in a rodent
model of schizophrenia. Mol Psychiatry. 2013 Nov;18(11):1193-8.
Shah A, Lodge DJ. A loss of hippocampal
perineuronal nets produces deficits in dopamine system function: relevance to
the positive symptoms of schizophrenia. Transl Psychiatry. 2013 Jan
Perez SM, Shah A, Asher A, Lodge DJ. Hippocampal deep brain
stimulation reverses physiological and behavioural deficits in a rodent model
of schizophrenia. Int J Neuropsychopharmacol. 2013 Jul;16(6):1331-9
Lodge DJ, Grace AA. Hippocampal dysregulation of
dopamine system function and the pathophysiology of schizophrenia. Trends
Pharmacol Sci. 2011 Sep;32(9):507-13.