y-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in
the mammalian brain. Dysfunctions of GABA-mediated inhibition have been
implicated in the etiology of a variety of brain disorders such as
epilepsy. Furthermore, GABA receptors are a target for a variety of
therapeutic, neuroactive compounds such as benzodiazepines and
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fluorescence reveals distinct structural changes induced in the human
rho 1 GABA receptor by inhibitory neurosteroids.Mol Pharmacol. 2010 Apr;77(4):539-46.
Khatri A, Sedelnikova A, Weiss DS.Sructural Rearrangements in Loop F of the GABA Receptor Signal LIgand Binding, Not Channel Activation. Biophys J. 2009 Jan:96(1):45-55.
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Wotring VE, Weiss, DS. Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity. J Gen Physiol. 2008 Jan;131(1):87-97.