Dr. Bacich's research focuses on prostate cancer, specifically the prostate cancer antigen, Prostate Specific Membrane Antigen (PSMA), which is a unique folate hydrolase that is highly expressed in prostate cancer.
The folate hydrolase activity spurred his interest in the effect of folate on prostate cancer initiation and progression. This area of research is particularly relevant, given the requirement for folate for cancer cell division as well as it being required for genomic stability and methylation reactions, thus it can have positive or negative consequences depending the stage of the cancer, and yet patient intake of folate can be easily modified by dietary modification.
This in turn has led to his interest in how folate levels modulate FASN expression and regulation, and the potential interaction of folate with FASNâ€™s nuclear localization.
Yao, V., Berkman, CE, Choi JK, Oâ€™Keefe, DS* and Bacich, DJ* (2010). Expression of Prostate-Specific Membrane Antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. * these authors contributed equally to this
manuscript. Prostate 70(3) 305-16. PMID 19830782.
Yao, V., Parwani, A., Maier, C., Heston, WDW., Bacich, DJ (2008) Moderate Expression of Prostate Specific Membrane Antigen, a Tissue Differentiation Antigen and Folate Hydrolase, Facilitates Prostate Carcinogenesis. Cancer Research 68(21):9070-7. PMCID 133339
Yao, V and Bacich DJ. (2006) Prostate Specific Membrane Antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro. Prostate 66:867-875
Bacich D.J., Wozniak, K., Lu, M., Oâ€™Keefe, D. S. , Callizot, N., Heston, W.D.W. and Slusher, B.S. (2005) Mice lacking Glutamate Carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury. J Neurochem. 2005 Oct;95(2):314-23.
Gregor PD, Wolchok JD, Turaga V, Latouche JB, Sadelain M, Bacich D, Heston WD, Houghton AN, Scher
HI (2005) Induction of autoantibodies to syngeneic prostate-specific membrane antigen by xenogeneic vaccination. Int. J Cancer 116:415-21
O'Keefe DS, Bacich DJ, Heston WD. (2004) Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. Prostate 58:200-10
Balaji KC, Rao PS, Smith DJ, Louis S, Smith LM, Sherman S, Bacich DJ, Oâ€™Keefe D. (2004) Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model. Urologic Oncology 22:313-320.
Bacich, DJ, Ramadam, E, Oâ€™Keefe, DS, Bukhari, N, Wegorzewska, E, Ojeifo, O, Wrenn, CC, Bzdega, T,
Wroblewska, B, Heston, WDW, Neale JH. (2002) Deletion of the Glutamate Carboxypeptidase II Gene in
Mice reveals a second enzyme activity that hydrolyzes N-Acetylaspartylglutamate. J. Neurochem. 83:20-29
Bacich DJ, Pinto JT, Tong W, Heston WDW. (2001) Cloning, Expression, Genomic Localization and
Enzymatic activities of the murine homologue of Prostate-Specific Membrane Antigen / NAALADase /
Folh1. Mam. Genome 12 117-123