Social behavior, its serotonergic underpinnings and
developmental disruption of the social brain in autism, schizophrenia, and other
psychiatric disorders are the focus of Dr. Georgianna Gouldâ€™s research.
Her goals are to aid in developing improved
treatment interventions for sociability deficits, and to identify common temporal
and physiological vulnerabilities to environmental risk factors for
Her approach combines a battery
of drug-treatment sensitive translational behavior tests of sociability, cognition
and emotionality with in vitro measures
of monoamine receptor and transporter density and function, and circulating
levels of hormones such as oxytocin and corticosterone by immunoassay.
Her postdoctoral studies in the laboratory of Dr. Alan Frazer (Pharmacology) focused on the role of transporter function in
antidepressant action and on behavioral depression models in rats.
Dr. Lynette Daws is
her faculty sponsor, and together they investigate auxiliary monoamine transporters
as promising pharmaceutical targets.
Zhang WQ, Smolik CM, Barba-Escobedo PA, Gamez M, Sanchez JJ,
Javors MA, Daws LC, Gould GG. 2015. Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains. Neuropharmacology. 90:1-8.
Gould GG, Burke TF, Osorio MD, Smolik CM, Zhang WQ, Onaivi
ES, Gu TT, DeSilva MN, Hensler JG. 2014. Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice. Psychoneuroendocrinology. 39:158-69.
Barba-Escobedo PA, Gould GG. 2012. Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects. Genes
Brain Behav. 11:366-73.
Gould GG, Seillier A, Weiss G, Giuffrida A, Burke TF,
Hensler JG, Rock C, Tristan A, McMahon LR, Salazar A, O'Connor JC, Satsangi N,
Satsangi RK, Gu TT, Treat K, Smolik C, Schultz ST. 2012. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. Prog Neuropsychopharmacol Biol Psychiatry. 238:260-9.
Daws LC, Gould GG. 2011. Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther.
Lau BY, Mathur P, Gould GG, Guo S. 2011. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc
Natl Acad Sci U S A. 108:2581-6.