Dr. Glenn Toneyâ€™s research lies at the
intersection between neuroscience and cardiovascular biology. Studies
seek to improve treatment of cardiovascular diseases and stroke, which are the
leading causes of death and disability worldwide. Techniques in routine
use include electrophysiology, immunohistochemistry, tract tracing,
optogenetics, viral mediated gene transfer, mRNA/protein expression techniques,
confocal/fluorescence microscopy, sympathetic nerve recordings and hemodynamic
measures. One funded project seeks to restore normal cardiovascular
function in hypertensive subjects by correcting hyperexcitability of neurons
that drive sympathetic nerve discharge to peripheral cardiovascular
tissues. Another project models obstructive sleep apnea and seeks to
identify neuroadaptations to intermittent brain hypoxia. Our goal is to
determine which adaptations confer stroke neuroprotection and which may be
neutral or detrimental to neuron survival.
Bardgett ME, Holbein WW, Herrera-Rosales M, Toney GM. Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-Î±. Hypertension. 2014 Mar;63(3):527-34.
Pedrino GR, Calderon AS, Andrade MA, Cravo SL, Toney GM. Discharge of RVLM vasomotor neurons is not increased in anesthetized angiotensin II-salt hypertensive rats. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1781-9.
Sharpe AL, Calderon AS, Andrade MA, Cunningham JT, Mifflin SW, Toney GM. Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1772-80.
Chen QH, Andrade MA, Calderon AS, Toney GM. Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons. J Neurophysiol. 2010 Nov;104(5):2329-37.
Toney GM, Stocker SD. Hyperosmotic activation of CNS sympathetic drive: implications for cardiovascular disease. J Physiol. 2010 Sep 15;588(Pt 18):3375-84.