James D. Stockand, Ph.D.

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RESEARCH

Research in the Stockand laboratory focuses on ion channels and ion transport. We are particularly interested in the proteins involved in controlling ion movement into neurons and epithelial cells. The prior is important to excitability and how central neurons signal to each other and how peripheral neurons allow us to sense our environment.  Ion channels in the kidney play a central role in controlling blood pressure as they set circulatory volume and the water and electrolyte content of plasma. We focus on understanding biologically important mechanisms that affect physiology. The lab has a long publication history on the mechanisms of regulation, structure-function relations and physiologic function of Deg/ENaC ion channels, in which we have employed electrophysiology, live-cell optical/fluorescence imaging, biochemical and molecular biological approaches, as well as contemporary molecular genetics and assessment of renal function, blood pressure and behavior in live animals.

Selected Publications

Boiko N, Kucher V, Eaton BA, Stockand JD. Inhibition of neuronal degenerin/epithelial Na+ channels by the multiple sclerosis drug 4-aminopyridine. J Biol Chem. 2013 Mar 29;288(13):9418-27.

Stockand, JD.  Chapter 8: Renal Ion Channels, Electrophysiology of Transport and Channelopathies, in Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology (Alpern, R.J., Moe, O.W and Caplan, M. eds.) Elsevier Science, Amsterdam, The Netherlands. 2013.

Mironova E, Bugaj V, Roos KP, Kohan DE, Stockand JD. Aldosterone-independent regulation of the epithelial Na+ channel (ENaC) by vasopressin in adrenalectomized mice. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10095-100.

Boiko N, Kucher V, Stockand JD, Eaton BA. Pickpocket1 is an ionotropic molecular sensory transducer. J Biol Chem. 2012 Nov 16;287(47):39878-86.

Kucher V, Boiko N, Pochynyuk O, Stockand JD. Voltage-dependent gating underlies loss of ENaC function in Pseudohypoaldosteronism type 1. Biophys J. 2011 Apr 20;100(8):1930-9.

Professor

Department of Cellular and Integrative Physiology

Education

Ph.D., Physiology/Integrative
The University of Texas Health Science Center at Houston, 1996

B.S., Biochemistry and Genetics
Texas A&M University, 1991

Contact

Email: STOCKAND@UTHSCSA.EDU

Phone: 210-567-4332

Research Profile
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