Studies conducted in Dr. Lisa Gerakâ€™s lab investigate the behavioral effects of drugs, primarily benzodiazepines and opioids. Although the therapeutic potential of these drugs is undeniable, their clinical utility is reduced by adverse effects, including abuse liability and the development of tolerance and dependence.
This laboratory investigates the acute and chronic effects of opioids and benzodiazepines with a major focus on physical dependence and withdrawal. Highly quantitative behavioral and pharmacological procedures are used to improve our understanding of dependence and identify strategies to minimize the consequences of withdrawal.
Gerak LR, France CP. Discriminative stimulus effects of pregnanolone in rhesus monkeys. Psychopharmacology (Berl). 2014 Jan;231(1):181-90.
Zanettini C, France CP, Gerak LR. Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: Determination of the functional half life of flumazenil. Eur J Pharmacol. 2014 Jan 15;723:405-9.
Maguire DR, Gerak LR, France CP. Effect of delay on self-administration of remifentanil under a drug versus drug choice procedure in rhesus monkeys. J Pharmacol Exp Ther. 2013 Dec;347(3):557-63.
Zanettini C, Yoon SS, France CP, Gerak LR. Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.. Eur J Pharmacol. 2013 Jan 30;700(1-3):159-64.
Eppolito AK, France CP, Gerak LR. Effects of acute and chronic morphine on delay discounting in pigeons. J Exp Anal Behav. 2013 May;99(3):277-89.