Dr. Andrew Cap is a hematologist conducting basic and translational research on coagulation system function and cellular therapy products for use in trauma and burn care. His mission is to lead the U.S. Army Institute of Surgical Research Coagulation and Blood Research Group. He also serves as a staff Hematologist-Oncologist at the San Antonio Military Medical Center (SAMMC), as a core faculty member its Hematology-Oncology Fellowship Program, as Program Director for the Clinical Investigation Fellowship Program and as an Associate Professor of Medicine at the Uniformed Services University. He is a board certified internist and hematologist-oncologist and serves as hematology and blood products subject matter expert advisor to the Joint Trauma System (JTS), US Pacific Command, and the US Special Operations Command (SOCOM).
His overall research goals are to decrease battlefield mortality, with emphasis on providing diagnostic and therapeutic interventions to treat hemorrhage and the coagulopathy of trauma. The mission of the Blood and Coagulation program has been focused on defining the pathophysiologic effects of trauma on the coagulation system. Specifically, they are analyzing new diagnostics and interventions to understand the role of platelets, cell-derived microparticles, and transfusion strategies in prevention or creation of clots that occur in trauma and burned soldiers. Their goal is to improve storage, preparation, and efficacy of blood products delivered to the far-forward battlefield.
James A. Bynum, M. Adam Meledeo, Todd M. Getz, Armando C. Rodriguez, James K. Aden, Andrew P. Cap, Heather F. Pidcoke. Bioenergetic Profiling of Platelet Mitochondria during Storage: 4Â°C Storage Extends Platelet Mitochondrial Function and Viability. Transfusion. Accepted for publication Jan 15, 2016.
Todd M. Getz, Robbie K. Montgomery, James A. Bynum, James K. Aden, Heather F. Pidcoke and Andrew P. Cap. Storage of platelets at 4Â°C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses. Transfusion. Epub 8 Feb 2016.
Kristin M. Reddoch, Robbie K. Montgomery, Armando C. Rodriguez, M. Adam Meledeo, Heather F. Pidcoke, Anand K. Ramasubramanian, Andrew P. Cap. Endothelium-derived inhibitors efficiently attenuate the aggregation and adhesion responses of refrigerated platelets. Shock. Vol 45, Issue 2, February 2016, pages 220â€“227.
Andrew P. Cap. Platelet storage: a license to chill! Transfusion. Volume 56, Issue 1, Jan 2016. pages 13â€“16.
Xiaowu Wu, Daniel N Darlington, Andrew P Cap. Procoagulant and Fibrinolytic Activity after Polytrauma in Rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. December 2015 Vol. no. , DOI: 10.1152/ajpregu.00401.2015
Daniel N Darlington, Mary D Gonzales, Teresa Craig, Michael A Dubick, Andrew P Cap, Martin G Schwacha. Trauma-induced coagulopathy is associated with a complex inflammatory response in the rat. Shock. Vol 44, August 2015. Pages 129-137.
Heather F Pidcoke, Claire L Isbell, Maryanne C Herzig, Chriselda G Fedyk, Beverly S Schaffer, Kevin K Chung, Christopher E White, Steven E Wolf, Charles E Wade, Andrew P Cap. Acute blood loss during burn and soft tissue excisions: An observational study of blood product resuscitation practices and focused review. Journal of Trauma and Acute Care Surgery. Vol 78, Issue 6. June 2015. Pages S39-S47.
Nicolas J Prat, Robbie Montgomery, Andrew P Cap, Michael A Dubick, Jean-Claude Sarron, Casimir Destombe, Philippe May, Pascal Magnan.Comprehensive evaluation of coagulation in swine subjected to isolated primary blast injury. Shock. Vol 43, Issue 6, June 2015. Pages 598-603.
James Eric Campbell, James Keith Aden, Andrew Peter Cap. Acute traumatic coagulopathy: Whole blood thrombelastography measures the tip of the iceberg. Journal of Trauma and Acute Care Surgery. Vol 78, Issue 5, May 2015. Pages 955-961.
Pidcoke HF, McFaul SJ, Ramasubramanian AK, Parida BK, Mora AG, Fedyk CG, Valdez-Delgado KK, Montgomery RK, Reddoch KM, Rodriguez AC, Aden JK, Jones JA, Bryant RS, Scherer MR, Reddy HL, Goodrich RP, Cap AP. Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time. Transfusion. 2013 Jan;53 Suppl 1:137S-149S. doi: 10.1111/trf.12048. PMID:23301966