Dr. Luis Giavedoni's principal research interests include the study of viral infections and the development of vaccines against such infections.
Our lab specifically works in understanding the innate and adaptive immune responses to retroviral infections in animal models of natural and experimental infections, and in identifying correlates of vaccine-induced protection against infection with filoviruses.
We study the role of cytokines and co-stimulatory proteins, molecules that mediate
communication between the immune system and the whole organism. Our laboratory has been developing reagents for the identification of cytokines in
nonhuman primates (NHP) and also studying the potential use of these molecules
to modify the outcome of immune responses. Research programs also aim at
therapeutic approaches by controlling or eliminating the virus in NHP infected
Our laboratory also serves as the Immunology Core Laboratory for the Southwest National Primate Research Center (SNPRC); we support the work of other scientists by:
1) providing assays based in flow cytometry for the characterization and isolation of blood cell subsets and the determination of cell mediated activity (T-cell proliferation, cytotoxic and natural killer cell activity) in nonhuman primate species;
2) providing methodologies for the simultaneous determination of multiple cytokines and chemokines in biological fluids derived from nonhuman primate species; and
A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W,
Giavedoni LD, Sodora DL. 2011. Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques. Curr HIV Res 9:276-288.
Pascutti MF, Rodriguez AM, Falivene J, Giavedoni L, Drexler I, Gherardi MM.
2011. Interplay between modified vaccinia virus Ankara and dendritic cells: phenotypic and functional maturation of bystander dendritic cells. J Virol 85:5532-5545.
Sariol CA, Martinez MI, Rivera F, Rodriguez IV, Pantoja P, Abel K, Arana T,
Giavedoni L, Hodara V, White LJ, Anglero YI, Montaner LJ, Kraiselburd EN. 2011. Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques. PLoS One 6:e19323.
Belshan M, Kimata JT, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R,
Hodara V, Giavedoni L, Hirsch V, Ratner L. 2012. Vpx is critical for SIVmne infection of pigtail macaques. Retrovirology 9:32.
Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K,
Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M, Jr., Chertova
E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF. 2013. Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies. J Virol
Fraietta JA, Mueller YM, Yang G, Boesteanu AC, Gracias DT, Do DH, Hope JL,
Kathuria N, McGettigan SE, Lewis MG, Giavedoni LD, Jacobson JM, Katsikis PD.
2013. Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS Pathog 9:e1003658.
Giavedoni LD, Chen HL, Hodara VL, Chu L, Parodi LM, Smith LM, Sexton V,
Cappelli D, Sodora DL. 2013. Impact of mucosal inflammation on oral simian immunodeficiency virus transmission. J Virol 87:1750-1758.
Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A,
Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB. 2013. GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees. Gastroenterology 144:1508-1517, 1517
Turk G, Ghiglione Y, Falivene J, Socias ME, Laufer N, Coloccini RS, Rodriguez
AM, Ruiz MJ, Pando MA, Giavedoni LD, Cahn P, Sued O, Salomon H, Gherardi MM.
2013. Early Gag immunodominance of the HIV-specific T-cell response during acute/early infection is associated with higher CD8+ T-cell antiviral activity and correlates with preservation of the CD4+ T-cell compartment. J Virol
Ghiglione Y, Falivene J, Ruiz MJ, Laufer N, Socias ME, Cahn P, Giavedoni L,
Sued O, Gherardi MM, Salomon H, Turk G. 2014. Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression. PLoS One
Hodara VL, Parodi LM, Chavez D, Smith LM, Lanford R, Giavedoni LD. 2014. Characterization of gammadeltaT cells in naive and HIV-infected chimpanzees and their responses to T-cell activators in vitro. J
Med Primatol 43:258-271.
Falivene J, Ghiglione Y, Laufer N, Eugenia Socias M, Pia Holgado M, Julia Ruiz
M, Maeto C, Ines Figueroa M, Giavedoni LD, Cahn P, Salomon H, Sued O, Turk G,
Magdalena Gherardi M. 2015. Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression. Sci