LuZhe Sun, Ph.D.

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RESEARCH

Dr. LuZhe Sun's laboratory studies molecular mechanisms that regulate cancer development, growth, invasion, and metastasis, and novel experimental therapeutics for cancer prevention and treatment using molecular and cellular biology, and bioinformatics techniques and animal model systems. 

Ongoing research projects include the investigation of how aging, obesity, radiation, and xenoestrogens may induce a tumorigenic phenotype of mammary stem cells and the investigation of the roles of transforming growth factor-beta (TGFβ), hedgehog, and androgen signaling pathways in various types of cancer. 

They are developing therapeutic approaches for the prevention of aging-associated breast cancer and for abrogating TGFβ, hedgehog, and androgen signaling pathways for the treatment of aggressive cancers including castration resistant prostate cancer.

Selected Publications

Mishra, S., Janice J. Deng, Pramod S. Gowda, Manjeet K. Rao, Chun-Lin Lin, Chun Liang Chen, Tim Huang, and Lu-Zhe Sun. Androgen Receptor and MicroRNA-21 axis down-regulates Transforming growth factor beta Receptor II (TGFBR2) expression in Prostate Cancer. Oncogene 33, 4097–4106, 2014. 

Biswas, T, Xiang Gu, Junhua Yang, Lesley G. Ellies, and Lu-Zhe SunAttenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Letters 346:129-138, 2014. 

Wang, D., Hui Gao, Abhik Bandyopadhyay, Anqi Wu, I-Tien Yeh, Yidong Chen, Yi Zou Changjiang Huang, Christi A. Walter, Qiaoxiang Dong, Lu-Zhe SunPubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell (MaSC) Function Leading to Early Neoplasia in Regenerated Glands. Cancer Prev Res. 7(4): 445-455, 2014. 

Mishra, S., Chun-Lin Lin, Tim H-M Huang, Hakim Bouamar, and Lu-Zhe SunMicroRNA-21 inhibits p57Kip2 expression in prostate cancer. Mol. Cancer, 13:212, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25216674

Professor

Cell Systems and Anatomy

Education

Ph.D., Physiology, Rutgers, The State University of New Jersey and UMDNJ, 1990

M.S, Physiology, Rutgers, The State University of New Jersey, 1985
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B.S., Agricultural Science, Shanghai Fisheries College, PRC, 1982

Contact

Email: SUNL@UTHSCSA.EDU
Phone: 210-567-5746

Research Profile
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Graduate Students

Carla Zellabos Torrez