The laboratory of Dr. Naomi Sayre is interested in the
processes that affect repair and recovery after brain damage, with particular
emphasis on the role that cholesterol homeostasis plays in these processes. Our
research focuses on understanding how cholesterol homeostasis affects two cell
types-astrocytes and neural stem cells. As the primary supportive cells in the
brain, astrocytes also regulate cholesterol homeostasis, and so have unique
potential to affect recovery after brain damage due to trauma or stroke. Neural
stem cells travel to the site of brain injury, where they play a role in
recovery that has not been fully elucidated.
L. Sayre, Mikaela Sifuentes, Deborah Holstein, Sheue-yann Cheng, Xuguang Zhu, James
D. Lechleiter. Stimulation of astrocyte
fatty acid oxidation by thyroid hormone is protective against ischemic
stroke-induced damage. JCBFM in
Sayre NL, Rimkunas VM, Graham MJ, Crooke RM, Liscum L. Recovery from liver disease in a Niemann-Pick type C mouse model. J Lipid Res. 2010 Aug;51(8):2372-83. doi: 10.1194/jlr.M007211. Epub 2010 Apr 24.
Sayre NL, Chen Y, Sifuentes M, Stoveken B, Lechleiter JD. Purinergic receptor stimulation decreases ischemic brain damage by energizing astrocyte mitochondria. Adv Neurobiol. 2014;11:121-50. doi: 10.1007/978-3-319-08894-5_7.
Chocron ES, Sayre NL, Holstein D, Saelim N, Ibdah JA, Dong LQ, Zhu X, Cheng SY, Lechleiter JD. The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism. Mol Endocrinol. 2012 Jul;26(7):1117-28. doi: 10.1210/me.2011-1348. Epub 2012 May 8.