Dr. Patricia Dahia is a tenured associate
professor in the Department of Medicine at the University of Texas Health
Science Center at San Antonio (UTHSCSA), and a member of the Cancer Therapy and
Research Center (CTRC), the NCI-designated Cancer Center at UTHSCSA. Her
research program is centered on the study of hereditary malignancies as model
systems to characterize genetic heterogeneity in cancer and to uncover intersections
between oncogenic and metabolic pathways.
Dr. Dahiaâ€™s goal is to understand how
dysfunction of these genes contributes to oncogenesis, and to use this
knowledge towards improved diagnosis, risk assessment, prognostic modeling,
and the development of personalized therapeutic strategies.
Qin Y, Deng Y, Ricketts CJ, Srikantan S, Wang E, Maher ER, Dahia PL. The tumor susceptibility
gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal
function. Hum Mol Genet. 2014 Jan 12.
Dahia PL. Pheochromocytoma
and paraganglioma pathogenesis: learning from genetic heterogeneity. Nat
Rev Cancer. 2014 Feb;14(2):108-19.
Toledo RA, Qin Y, Srikantan S, Morales NP, Li Q, Deng Y, Kim SW, Pereira MA,
Toledo SP, Su X, Aguiar RC, Dahia PL. In vivo and in vitro
oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas.
Endocr Relat Cancer. 2013 May 21;20(3):349-59.
Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD,
Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP,
Stiles C, Aguiar RC, Dahia PL. Germline mutations in
TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010
Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M,
Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy
R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J,
Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, NosÃ© V, Li C, Stiles CD. A HIF1alpha regulatory loop
links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet.