Dr. Ricardo Aguiar's lab is centered on the identification and functional characterization of the genetic abnormalities found in hematologic malignancies. Our ultimate goals are to better understand the pathogenesis and to develop novel targeted therapeutic strategies for these diseases.
Our principal disease model is B-cell lymphoma. Active research lines stem from our recently published work and include: 1) Detailed characterization of the intersection between cAMP signals and multiple survival pathways in lymphomas, towards the validation of phosphodiesterase 4 inhibitors for the treatment of lymphoid tumors; 2) Lymphomagenic intersection between microRNAs, the TGFÎ² and NF-ÎºB pathways; 3) Interplay between metabolic imbalance, epigenetics and lymphoma biology; 4) Discovery of new chromosomal translocations in B-cell lymphomas.
Bouamar H, Jiang D, Wang L, Lin AP, Ortega M, Aguiar RC. MicroRNA 155 Control of p53 Activity Is Context Dependent and Mediated by Aicda and Socs1. Mol Cell Biol. 2015 Apr 15;35(8):1329-40.
Jiang D, Aguiar RC. MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-Î²1/SMAD5 signaling module.Blood. 2014 Jan 2;123(1):86-93.
Bouamar H, Abbas S, Lin AP, Wang L, Jiang D, Holder KN, Kinney MC, Hunicke-Smith S, Aguiar RC. A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma. Blood. 2013 Aug 1;122(5):726-33.
Kim SW, Ramasamy K, Bouamar H, Lin AP, Jiang D, Aguiar RC. MicroRNAs miR-125a and miR-125b constitutively activate the NF-ÎºB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci U S A. 2012 May 15;109(20):7865-70.
Kim SW, Rai D, Aguiar RC. Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma. Clin Cancer Res. 2011 Nov 1;17(21):6723-32.
Rai D, Kim SW, McKeller MR, Dahia PL, Aguiar RC. Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3111-6.