Robert A. Clark, M.D.

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Dr. Robert Clark's lab carries out basic and translational research relevant to human diseases, with a major focus on mechanisms of the inflammatory response and oxidative stress, as well as the cell biology and biochemistry of human phagocytic cells. 

We have contributed to fundamental understanding of the generation of reactive oxygen species (ROS) by the phagocyte NADPH oxidase system, the biological roles of these products, and the genetics and biochemistry of NADPH oxidase deficiency.

In recent years, we have turned our attention to the structure, function, and physiologic roles of several novel non-myeloid members of the NADPH oxidase (NOX) gene family, focusing particularly on the involvement of these oxidases in disease pathogenesis and the transcriptional regulation of genes that are relevant to the biology of aging. Our recent studies include mechanistic work on neurodegenerative disorders, especially Parkinson’s disease.

Selected Publications

Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A. NOX5 in human spermatozoa: Expression, function and regulation. J Biol Chem 287(12):9376-9388, 2012.

Biju KC, SantacruzRA, Chen C, Zhou Q, Yao J, Rohrabaugh SL, Clark RA, Roberts JL, Phillips KA, Imam SZ, Li S. Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease. Neurosci Letters 535:24-29, 2013.

Le T, Wright EJ, Smith DM, He W, Catano G, Okulicz JF, Young JA, Clark RA, Richman DD, Little SJ, Ahuja SK. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med 368(3):218-230, 2013.

Imam SZ, Trickler W, Kimura S, Binienda ZK, Paule MG, Slikker Jr. W, Li S, Clark RA, Ali SF. Neuroprotective efficacy of a new brain-penetrating c-Abl inhibitor in a murine Parkinson’s disease model. PLoS ONE 8(5): e65129, 2013. 

Okulicz JF, Le TD, Agan BK, Camargo JF, Landrum ML, Wright E, Dolan ML, Ganesan A, Ferguson TM, Smith DM, Richman DD, Little SL, Clark RA, He W, Ahuja SK. Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals. JAMA Intern Med 174(11):1-12.

Assistant Vice President for Clinical Research
Office of the VPR

Medicine/ Barshop/ Cellular and Integrative Physiology


M.D., Medicine, Columbia University, College of Physicians and Surgeons, 1967

A.B., Mathematics, Syracuse University, 1963



Phone: (210) 567-0866

Research Profile
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