Dr. Samy Habib joined the Department of Cell Systems and Anatomy in April 2011. He also hold the position as Research Scientist in the
South Texas Veterans Health Care System at Audie Murphy VA Hospital since 2005.
He was a recipient of several research grant awards from American Diabetes
Association, American Heart Association, National Kidney Foundation, New
Investigator Award and Merit Review Award from Veterans Affairs, and Pilot
Reserach Award from NIH/NIDDK. He has recently received the Excellent of
Performance Award from the VA. Dr. Habib has been a regular member of the
Kidney Cancer Study Section of the Medical Research Program, Department of
Defense. He is also an editorial board member of 5 journals.
The major emphasis of the work in my laboratory is on
identifying the molecular mechanisms mediating fibrosis, hypertrophy and
apoptosis in diabetic nephropathy, as well as defining the role of diabetes in
the development of renal tumors. Novel finding from our lab confirmed that
tuberin, a tumor suppressor protein, regulates the DNA repair enzyme OGG1
pathway. Dysregulation of this pathway leads to accumulation of oxidative DNA
damage and predisposes tissue to cancer. Our studies are carried out in
cultured cells, animal models, and in kidney tumors of patient with Tuberous
Sclerosis Complex(TSC) disease.
Velagapudi C, Bhandari BS, Abboud-Werner S, Simone S, Abboud HE, Habib SL. (2011)
The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes. J Am Soc Nephrol. 2011 Feb;22(2):262-73.
Habib SL, Bhandari BK, Sadek N, Abboud-Werner SL, Abboud HE. (2010)
Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells. Carcinogenesis. 2010 Nov;31(11):2022-30.
Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu H, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B. (2010)
S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J. 2010 Sep 1;29(17):2994-3006.
Habib SL, Kasinath BS, Arya RR, Vexler S, Velagapudi C. (2010)
mechanism of reducing tumourigenesis: upregulation of the DNA repair
enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition. Eur J Cancer. 2010 Oct;46(15):2806-20.
Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G. (2009)
TSC2 deficiency increases PTEN via HIF1alpha. J Biol Chem. 2009 Oct 9;284(41):27790-8.