Dr. Shamimunisa B. Mustafa lab's research interests primarily lie in the area of regulation of lung
epithelial ion transport via sodium channels.
They are interested in the
regulation of sodium channels by synthetic glucocorticoids, cAMP, and
proinflammatory mediators. Another main area of interest is the effects of synthetic analogs of
dexamethasone in the premature lung. The use of postnatal dex to
alleviate respiratory disease in premature babies is limited because of
the long-term growth retardation of the developing lung and associated
neurological defecits in children that were exposed to postnatal dex as
The synthetic analogs are currently being assessed in
non-human primate lung tissue, mainly they are looking at the efficacy of
these agents in elevating markers of lung maturation, e.g. surfactant
associated proteins and sodium channels.
In early preterm lung tissue, they are also investigating the effect of these analogs on angiogenic growth
factors which are known to promote lung development, in particular,
They are also pursuing the area of lung development in caveolin-1 deficient
newborn mice, as these mice, as adults are highly susceptible to
respiratory infection and do present with lung disease similar to the
human lung diseases of COPD and pulmonary fibrosis.
Jupelli M, Murthy AK, Chaganty BK, Guentzel MN, Selby DM, Vasquez MM,
Mustafa SB, Henson BM, Seidner SR, Zhong G, Arulanandam BP. Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. Lab Invest. 2011 Oct;91(10):1530-9.
Vasquez MM, Mustafa SB, Choudary A, Seidner SR, Castro R. Regulation of epithelial Na+ channel (ENaC) in the salivary cell line SMG-C6. Exp Biol Med (Maywood). 2009 May;234(5):522-31.
Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR. Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC). J Cell Physiol. 2008 Apr;215(1):101-10.
Kerecman J, Mustafa SB, Vasquez MM, Dixon PS, Castro R. Immunosuppressive properties of surfactant in alveolar macrophage NR8383. Inflamm Res. 2008 Mar;57(3):118-25.
Vasquez MM, Castro R, Seidner SR, Henson BM, Ashton DJ, Mustafa SB. Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. J Cell Physiol. 2008 Dec;217(3):632-42.