With the use of genomic microarrays covering the 18q21-18q23 region, Dr. Teresa Johnson-Pais's lab has performed array comparative genomic hybridization (array CGH) experiments using
prostate cancer specimens and have identified a copy number gain at 18q22.1. This
region includes the gene for cadherin 7.
The cadherins are a superfamily of
transmembrane glycoproteins that mediate cellular adhesion. We are developing a
transgenic mouse that overexpresses cadherin-7 to determine the role that increased
copies of this gene plays in prostate cancer progression.
We are also investigating the homozygous loss of sequences at 18q detected by
array CGH in 58 percent of prostate tumors and 70 percent of breast tumors. We have identified a
novel transcript that is encoded in this region of loss and are in the process of
characterizing this transcript.
Mohamed GH, Gelfond JA, Nicolas MM, Brand TC, Sarvis JA, Leach RJ, Johnson-Pais TL. Genomic characterization of testis cancer: association of alterations with outcome of clinical stage 1 mixed germ cell nonseminomatous germ cell tumor of the testis. Urology. 2012 Aug;80(2):485.e1-5.
Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem. 2011 Jul 1;286(26):23003-11.
Beuten J, Gelfond JA, Franke JL, Shook S, Johnson-Pais TL, Thompson IM, Leach RJ. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):588-99.
Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, Garza-Guajardo R,
Johnson-Pais T, Beuten J, Morales-Rodriguez IB, Hernandez-OrdoÃ±ez MA,
Calderon-Cardenas G, Ortiz-Lopez R, Rivas-Estilla AM, Ancer-Rodriguez J,
Rojas-Martinez A. Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer. 2010 Jun 24;10:326.
Walss-Bass C, Soto-Bernardini MC, Johnson-Pais T, Leach RJ, Ontiveros A,
Nicolini H, Mendoza R, Jerez A, Dassori A, Chavarria-Siles I, Escamilla
MA, Raventos H. Methionine sulfoxide reductase: a novel schizophrenia candidate gene. Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):219-25.