Xiao-Dong Chen, M.D., Ph.D.

Xiao-dong chen 023


The goal of Dr. Xiao-Dong Chen's lab is to reconstitute tissue-specific stem cell niche in vitro to control stem cell fate for tissue regenerative purposes.

Selected Publications

Antebi B, Cheng X, Harris JN, Gower LB, Chen XD, Ling J.Biomimetic collagen-hydroxyapatite composite fabricated via a novel perfusion-flow mineralization technique.Tissue Eng Part C Methods. 2013 Jul;19(7):487-96.

Sun Y, Li W, Lu Z, Chen R, Ling J, Ran Q, Jilka RL, Chen XD. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J. 2011 May;25(5):1474-85.

Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD. Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev. 2010 Jul;19(7):1095-107.

Chen XD. Extracellular matrix provides an optimal niche for the maintenance and propagation of mesenchymal stem cells.Birth Defects Res C Embryo Today. 2010 Mar;90(1):45-54.

Chen XD, Dusevich V, Feng JQ, Manolagas SC, Jilka RL. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res. 2007 Dec;22(12):1943-56.

Comprehensive Dentistry/Barshop


M.S., Computer Science in Bioinformatics, John Hopkins University Engineering, 2003

Ph.D., Developing Immunology, University of Nebraska Medical Center, 1993

M.S., Hematology, University of Nebraska Medical Center, 1990

M.D., Medicine, Shanghai Jiao-Tong University School of Medicine, 1983



Phone: (210) 562-4130

Research Profile
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Graduate Students

Travis Block
Biomedical Engineering (Ph.D.)

Milos Marinkovic
Biomedical Engineering (Ph.D.)

Rubie Rakian
IMGP/Physiology (D.D.S./Ph.D.)