Xin-Yun Lu, Ph.D.

Xin-yun lu Xin-yun lu-1

RESEARCH

My laboratory studies the molecular mechanisms and neural circuits underlying mood and metabolic disorders. Our current research focuses on the roles of adipose-derived hormones, such as leptin and adiponectin, in regulating neuronal plasticity (synaptogenesis and neurogenesis), cognition and emotion. We utilize neuron-specific transgenic mouse models, various types of stress and behavioral paradigms, in vivo and in vitro electrophysiology, in vivo real-time neurochemical monitoring and neuronal tracing techniques to understand how adipose-derived hormones communicate with the brain to contribute to the pathogenesis of major depression, post-traumatic stress disorder and cognitive dysfunction and further explore their therapeutic potential for these psychiatric disorders.


Selected Publications

Liu J, Garza JC, Li W, Lu XY. Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion.Int J Neuropsychopharmacol. 2013 Feb;16(1):105-20.

Guo M, Huang TY, Garza JC, Chua SC, Lu XY. Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol. 2013 May;16(4):857-67.

Guo M, Lu Y, Garza JC, Li Y, Chua SC, Zhang W, Lu B, Lu XY. Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Transl Psychiatry. 2012;2:e83.

Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer PE, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12248-53. 

Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry. 2012 Jul;17(8):790-808.  

Wang X, Zhang D, Lu XY. Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin. Mol Psychiatry. 2014 Aug 5. doi: 10.1038/mp.2014.75.

Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer PE, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12248-53.

Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry. 2012 Jul;17(8):790-808.

Zhang D, Guo M, Zhang W, Lu XY. Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade. J Biol Chem. 2011 Dec 30;286(52):44913-20.

Liu J, Perez SM, Zhang W, Lodge DJ, Lu XY. Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala. Mol Psychiatry. 2011 Oct;16(10):1024-38.

Associate Professor
Pharmacology

Education

Ph.D., Pharmacology, Washington State University, 1998

M.S., Biochemistry, Zhanjiang Medical College, 1990

Contact

Email: LUX3@UTHSCSA.EDU

Phone: 210-567-0803

Research Profile
More Info...

Graduate Students

Xing Fang