Yan Xiang, Ph.D.

Noprofile Yan xiang

RESEARCH

The primary interest of Dr. Yan Xiang's laboratory is host-pathogen interactions, with poxviruses as our model systems. Variola virus and molluscum contagiosum virus (MCV) are the only two members of poxvirus family that exclusively infect humans and cause human diseases. Variola virus is the causative agent of smallpox. A closely related poxvirus, vaccinia virus, serves as the vaccine for smallpox. 

However, the vaccination causes a relatively high level of immunization complications. MCV is still prevalent throughout the world. Unlike smallpox virus, MCV causes small, benign skin lesions in children and young adults and a more extensive disease only when there is a concurrent immunodeficiency such as AIDS. We are trying to understand the molecular mechanisms of poxviral pathogenesis by uncovering the functions of various poxviruses virulence factors. 

Selected Publications

Benhnia MR, Maybeno M, Blum D, Aguilar-Sino R, Matho M, Meng X, Head S, Felgner PL, Zajonc DM, Koriazova L, Kato S, Burton DR, Xiang Y, Crowe JE Jr, Peters B, Crotty S. Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine. J Virol. 2013 Feb;87(3):1569-85.

Meng X, Wu X, Yan B, Deng J, Xiang Y. Analysis of the role of vaccinia virus H7 in virion membrane biogenesis with an H7-deletion mutant. J Virol. 2013 Jul;87(14):8247-53.

Meng X, Xiang Y. Generation and characterization of monoclonal antibodies specific for vaccinia virus. Methods Mol Biol. 2012;890:219-32.

Meng X, Embry A, Rose L, Yan B, Xu C, Xiang Y. Vaccinia virus A6 is essential for virion membrane biogenesis and localization of virion membrane proteins to sites of virion assembly. J Virol. 2012 May;86(10):5603-13.

Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice CM, Xiang Y. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol. 2012 Apr;86(8):4538-47.

Associate Professor
Microbiology, Immunology, and Molecular Genetics

Education

Ph.D.,Biochemistry, Case Western Research University, 1997

B.S., Molecular Biology, University of Science and Technology of China, 1992

Contact

Email: XIANGY@UTHSCSA.EDU

Phone: (210) 567-0884

Research Profile
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