The primary interest of Dr. Yan Xiang's laboratory is host-pathogen interactions, with poxviruses as our model systems. Variola virus and molluscum contagiosum virus (MCV) are the only two
members of poxvirus family that exclusively infect humans and cause
human diseases. Variola virus is the causative agent of smallpox. A
closely related poxvirus, vaccinia virus, serves as the vaccine for
However, the vaccination causes a relatively high level of
immunization complications. MCV is still prevalent throughout the world.
Unlike smallpox virus, MCV causes small, benign skin lesions in
children and young adults and a more extensive disease only when there
is a concurrent immunodeficiency such as AIDS. We are trying to
understand the molecular mechanisms of poxviral pathogenesis by
uncovering the functions of various poxviruses virulence factors.
Benhnia MR, Maybeno M, Blum D, Aguilar-Sino R, Matho M, Meng X, Head S,
Felgner PL, Zajonc DM, Koriazova L, Kato S, Burton DR, Xiang Y, Crowe JE
Jr, Peters B, Crotty S. Unusual
features of vaccinia virus extracellular virion form neutralization
resistance revealed in human antibody responses to the smallpox vaccine. J Virol. 2013 Feb;87(3):1569-85.
Meng X, Wu X, Yan B, Deng J, Xiang Y. Analysis of the role of vaccinia virus H7 in virion membrane biogenesis with an H7-deletion mutant. J Virol. 2013 Jul;87(14):8247-53.
Meng X, Xiang Y. Generation and characterization of monoclonal antibodies specific for vaccinia virus. Methods Mol Biol. 2012;890:219-32.
Meng X, Embry A, Rose L, Yan B, Xu C, Xiang Y. Vaccinia
virus A6 is essential for virion membrane biogenesis and localization
of virion membrane proteins to sites of virion assembly. J Virol. 2012 May;86(10):5603-13.
Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice CM, Xiang Y. C7L
family of poxvirus host range genes inhibits antiviral activities
induced by type I interferons and interferon regulatory factor 1. J Virol. 2012 Apr;86(8):4538-47.