Dr. Yidong Chen received his BS/MS degrees in Electrical Engineering from Fudan University, Shanghai, China, and Ph.D. in Imaging Science from Rochester Institute of Technology, Rochester, NY. He has been with Hewlett Packard Co as a Research Engineer before he joined National Institutes of Health (NIH) at 1996.
At NIH, Dr. Chen joined microarray technology development effort at National Human Genome Research Institute (NHGRI), as a Special Expert, Staff Scientist, and later Associate Investigator for microarray image, statistical analysis, and bioinformatics. From 2006-2008 he joined the Genetics branch at National Cancer Institute (NCI) as a staff scientist. During the 13-year period with NHGRI and NCI, he has contributed about 90 peer reviewed publications and book chapters.
His lab works on computational biology and bioinformatics and focuses on developing computational solution and statistical modeling to bridge between quatitative science and the basic biology and translational research within Greehey Childrenâ€™s Cancer Research Institute and around UT Health Science Center. Our research contributions are in:
- Support Genome Sequencing Facility (GSF) bioinformatics operation
- Develop Next-Generation Sequencing (NGS) data analysis methods
- Cancer genome profiling, gene expression analysis, Gene regulation networks, and
- Provide computational biology and biostatistics collaboration for pediatric cancer research
Mann M, Zou Y, Chen Y, Brann D, Vadlamudi R. PELP1 oncogenic functions involve alternative splicing via PRMT6. Mol Oncol. 2014 Mar;8(2):389-400.
Sanchez-Diaz PC, Hsiao TH, Chang JC, Yue D, Tan MC, Chen HI, Tomlinson GE, Huang Y, Chen Y, Hung JY. De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development. PLoS O ne. 2013 Apr 17;8(4):e61622.
Gu F, Doderer MS, Huang YW, Roa JC, Goodfellow PJ, Kizer EL, Huang TH, Chen Y. CMS: a web-based system for visualization and analysis of genome-wide methylation data of human cancers. PLoS One. 2013 Apr 22;8(4):e60980.
Flores M, Hsiao TH, Chiu YC, Chuang EY, Huang Y, Chen Y. Gene regulation, modulation, and their applications in gene expression data analysis. Adv Bioinformatics. 2013;2013:360678.
Meng J, Cui X, Rao MK, Chen Y, Huang Y. Exome-based analysis for RNA epigenome sequencing data. Bioinformatics. 2013 Jun 15;29(12):1565-7.