Yuzuru Shiio, M.D., Ph.D.

Yuzuru shiio

RESEARCH

Dr. Yuzuru Shiio's lab is employing a combination of quantitative proteomics technology and traditional molecular cell biology approaches. His laboratory studies the secreted mediators of cellular senescence, how IGFBP3, one of the secreted mediators of senescence we identified, inhibits the proliferation of Ewing sarcoma, children’s bone and soft tissue cancer, and the cytokine signaling in different children’s cancers.

Selected Publications

Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y. Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol. 2012 Nov;32(21):4388-99.

Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y. Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12052-7.

Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y. The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1. Arch Biochem Biophys. 2012 Feb 15;518(2):103-10.

Song M, Hakala K, Weintraub ST, Shiio Y. Quantitative proteomic identification of the BRCA1 ubiquitination substrates. J Proteome Res. 2011 Nov 4;10(11):5191-8.

Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. J Proteome Res. 2011 Nov 4;10(11):5175-82.

Associate Professor
Greehey CCRI/Biochemistry and Structural Biology

Education

Ph.D., Molecular Biology, University of Tokyo, 1993

M.D., Medicine, University of Tokyo, 1989

Contact

Email: SHIIO@UTHSCSA.EDU
Phone: (210) 562-9089

Research Profile
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